Effect of multiple-dose regimens of cyclooxygenase inhibitors and their combinations with mexidol on behavior in mature rats

Effects of multiple-dose regimens (oral, daily, once a day for 15 days) cyclooxygenase (COX) inhibitors etoricoxib (1 and 10 mg/kg), diclofenac sodium 5 mg/kg) their combinations with 2-ethyl-6-methyl-3-hydroxypyridine succinate (mexidol 25 on rat behavior were studied in the open field test, rotarod test elevated plus maze test. Exploratory (in test) locomotor rats was significantly weakened only by non-selective COX inhibitor at mg/kg, which is due to peripheral side effect drug. The selective COX-2 increased time central area 1 mg/kg reduced latent period locomotion mg/kg. A combination mexidol neither exploratory nor caused motor deficit contrast However, inhibited activity Nevertheless, it produced no significant effects or anxiety animals